by E. Cohen, Y. Xu, S. Ghodke, A. Orosco, D. Wang, C.N. Johnson, M.K. Sarkar, J.E. Gudjonsson, L. Marchal, A. Hovnanian, C. Parent, P.A. Coulombe | Aug 1, 2026 | Berries, Cosmetics, Ingredients
The stress-induced keratin intermediate filament gene, KRT16, and K16 protein are spatially restricted to the suprabasal layers of the epidermis and widely used as biomarkers in psoriasis, hidradenitis suppurativa, atopic dermatitis, and other inflammatory disorders....
by K. Fukuda, Y. Furuichi, R. Ozawa, T. Matsui, M. Amagai | Aug 1, 2026 | Berries, Cosmetics, Ingredients
The stratum corneum (SC), composed of dead keratinocytes (corneocytes), is vital for skin barrier function. We generated hairless mice expressing the ratiometric pH probe Venus–mCherry in the uppermost stratum granulosum cells (SG1 cells) and corneocytes (VmC mice),...
by S. Steiner, E. Horst, C.N. Johnson, E. Sprecher, L. Samuelov, E. O'Toole, G. Mehta, R. Iglesias Bartolome, P.A. Coulombe | Aug 1, 2026 | Berries, Cosmetics, Ingredients
The palmoplantar epidermis is distinct from other body sites, reflecting the mechanical strain it bears during locomotion. Pathogenic variants in over 50 genes are causative for palmoplantar epidermal differentiation disorders (pEDDs). One such disorder is KRT9-pEDD,...
by S. Kapur, M.A. Houdi, K. Nguyen, K.S. Sidhu, M. Bazzi, C. Burkhart | Aug 1, 2026 | Berries, Cosmetics, Ingredients
Hyperhidrosis is a chronic somatic condition characterized by eccrine sweat gland hyperactivity that may present as focal or generalized as a primary or secondary disorder. Pharmacologic management often involves anticholinergic agents, and many patients also receive...
by G. Guilarte, D. Lee, M. Motlak, H. Park, J. Tung, S. Choudhary, T.K. Le | Aug 1, 2026 | Berries, Cosmetics, Ingredients
Adverse childhood experiences (ACEs) are early-life stressors that disrupt neuroendocrine and immune development and may predispose individuals to chronic skin disease. We analyzed cross-sectional data from the nationally representative Health and Retirement Study...
by H. Ghani, Z. Haq, A. Qureshi, E. Cho | Aug 1, 2026 | Berries, Cosmetics, Ingredients
Vitiligo is a chronic autoimmune disorder characterized by melanocyte loss and is associated with significant psychosocial burden and diagnostic delay. Prior studies suggest associations with systemic autoimmune and psychiatric conditions; however, evidence from...
